Genesis Mission Launches as US Builds Closed-Loop AI System Linking National Laboratories

The United States has announced a major federal scientific initiative known as the Genesis Mission, framed by the administration as a transformational leap forward in how national research will be conducted. Revealed on November 24, 2025, the mission is described by the White House as the most ambitious federal science effort since the Manhattan Project. The accompanying executive order tasks the Department of Energy with creating an interconnected “closed-loop AI experimentation platform” that will join the nation’s supercomputers, 17 national laboratories, and decades of research datasets into one integrated system. 

Federal statements position the initiative as a way to speed scientific breakthroughs in areas such as quantum engineering, fusion, advanced semiconductors, biotechnology, and critical materials. DOE has called the system “the most complex scientific instrument ever built,” describing it as a mechanism designed to double research productivity by linking experiment automation, data processing, and AI models into a single continuous pipeline. The executive order requires DOE to progress rapidly, outlining milestones across the next nine months that include cataloging datasets, mapping computing capacity, and demonstrating early functionality for at least one scientific challenge. 

The Genesis Mission will not operate solely as a federal project. DOE’s launch materials confirm that the platform is being developed alongside a broad coalition of private, academic, nonprofit, cloud, and industrial partne

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